The most common and perhaps most debilitating of all the blood cancer treatment side-effects is cancer related fatigue (CRF).

This daily lack of energy and whole-body fatigue is not relieved with sleep, nor is it the result of over exertion. This fatigue makes it difficult to cope with the normal demands of daily living due to a total lack of energy. CRF is not to be confused with tiredness that is often felt at the end of a long day, where energy is restored after a good sleep.